Magnesium issue are the most entrancing and testing issue in pediatric and grown-up world. Renal magnesium taking care of is confused however fascinating. The vast majority of the rounded issue and different CaSR infection are new advancing issue with detail hereditary mapping. Every one of these scatters are very much clarified and a diagostic dillema when represented a sickness in nephrology world. I will portray the physiolgy and renal treatment of magnesium, examine the job of medication instigate hypomagnesemia and way to deal with magnesium issue. I will portray the varius hereditary scatters, analytic calculation and the board of hypomagnesemia. I will likewise examine the hypermagnesemia mangement and emanant treatment of electrolyte issue related with it.